The U.S. Animal Vaccinology Research Coordination Network is comprised of academic, government, and corporate vaccine researchers, brought together on a formal basis to identify current and future vaccine needs and opportunities in the US and to collaboratively set broad goals and priorities for addressing them. This is implemented through regular virtual meetings and online resources, and in-person conferences. The goal of the network is to act collectively to improve strategies for the timely development of, efficacious next generation vaccines, and flexible diagnostic platforms to monitor for emerging infectious diseases that have the potential for catastrophic impact on the U.S. agriculture industry. Network findings and suggestions are communicated on a regular basis to the USDA NIFA leadership to assist them with setting national research directions and funding priorities.