Faculty

Antonio Garmendia

Background
Contact
Courses Taught
Research Interests
Publications
Links

Background

Education

D.M.V (University of San Marcos)
Ph.D. (Washington State University)
Diplomate
A.C.V.M.

Contact

Department of Pathobiology and Veterinary Science University of Connecticut
61 North Eagleville Rd
Storrs, CT 06268
Email: Antonio.Garmendia@Uconn.Edu
Phone: 860-486-0821
Fax: 860-486-2794

Courses Taught

PVS 3201/PVS3201W: Principles of Animal Virology

PVS 5632: Vaccines: Mechanisms of Immune Protection (team taught)

PVS 5202 Viral Pathogenesis

Research Interests

Mechanisms of Protective Immunity against Viral infections- Modulation of the immune response by cytokines (Th1/Th2) in the context of protective immunity. Research with DNA vaccines, replication-defective adenoviral vaccines. Identification of protective viral proteins, vaccine delivery approaches. Current work with porcine reproductive and respiratory syndrome virus.

West Nile virus Research- There are many questions about WNV in North America that need to be addressed in terms of pathogenesis transmission, reservoirs, persistence and immunity, overwintering, vaccines etc. These areas are of interest in research in the immediate future. My laboratory is currently involved in the development and validation of rapid tests for the diagnosis of WNV infections.

Research on Llama Medicine- An area of research interest is llama (new world camelid) medicine, especially in the areas of diagnostic and research virology. My laboratory has started to develop diagnostic reagents for this species which are currently being evaluated by us and by a private laboratory. To strengthen this effort, I am seeking funding through the Morris Animal Foundation and local Lama Associations and also developing collaborations both at the national and the international levels.

Research on Exotic Viral Diseases of Animals- Through an Specific Cooperative Agreement (SCA) with Plum Island Animal Disease Center (PIADC) we have access to participate in research on exotic viral diseases of animals. A Joint Graduate Student Program I is under consideration. Under this Program, Graduate students will complete their course work and initial laboratory training at the University of Connecticut and then they will perform their research at the PIADC facility. The advisory committee will be composed by Faculty at the University of Connecticut and Research Scientists from PIADC. There are unique opportunities to study pathogenesis and immunology with exotic viruses.

Publications

Tulman, E. R. and A. E. Garmendia. 1994. Pseudorabies virus infectivity for swine skin characterized in vitro. Archives of Virology 136:149-159.
Tulman, E. R. and A. E. Garmendia. 1994. Delivery of pseudorabies envelope antigens enclosed in immuno stimulating complexes (ISCOMs): Elicitation of neutralizing antibody and lymphoproliferative responses in swine and protection in mice. Vaccine 12:1349-1354.
Garmendia A.E. and E.R. Tulman 1996. Detection of Lymphoproliferative responses against Pseudorabies Virus Immediate Early Protein (IE180) in Swine Immunized with a Modified Live Virus Vaccine. Viral Immunology 9:247-256.
Garmendia A.E. and E.R Tulman 1997. Discrete Cleavage Patterns of pseudorabies virus immediate early protein (IE180) seen in some cell lines upon extraction after cycloheximide reversal. J Virol Meth 64:171-179.
Garmendia A.E., S. Chang, E.R. Tulman, G. Rompato, And J. Bu 1998. Immunogenicity of vector DNA vaccine constructs of pseudorabies virus immediate early gene (IE180) in swine and mice. Ann. N.Y. Acad. of Sci.:481-485.
Chang S.W., J. Bu, G. Rompato, A.E. Garmendia 1998. Vector DNA Vaccine Encoding Pseudorabies Virus (PrV) Immediate Early Protein (IE180) Demonstrates Partial Protection in Mice against Lethal Virus Challenge. Viral Immunology 11:27-36.
Anderson J., T Andreadis, C.A. Vossbrink, S. Tirrel, E.M. Wakem, R.A. French, A.E. Garmendia and H.J. Van Kruiningen 1999. Isolation of West Nile virus from mosquitoes, crows and a Cooper's hawk in Connecticut. Science 286:2331-2333.
Garmendia A.E., H.J. Van Kruniningen, R.A. French, J.F. Anderson, T.G. Andreadis, A. Kumar and A.B. West 2000. Recovery and identification of West Nile virus form a hawk in winter. J Clin Microbiol 38:3110-3111.
Stasny B.R, S. De Guise, G. Rompato and A.E. Garmendia 2000. Functional characterization of a swine double positive CD4+/CD8+ T cell line with a CD25+/CD45RA- phenotype generated with interleukin-2. Vet Immunol and Immunopathol 78:57-70.
Garmendia A.E., H.J. Van Kruniningen and R.A. French 2001. The West Nile virus: its recent emergence in North America. Microbes and Infection 3:223-229
Novello A. ..A.E. Garmendia et al 2000. Update: West Nile virus activity Northeastern United States, January-August 2000. MMWR 49(31):714-717.
Eidson M. ....A.E. Garmendia et al 2001. Crow deaths as sentinel surveillance system for West Nile virus in Northeastern United States 1999. Emerging Infectious Diseases July-Aug 7(4):615-620. Bu J., G. Rompato, Y.H. Song, D.J. Burgess and A.E. Garmendia 2003. Co-delivery of IL-2 or augment the responses of mice to a DNA vaccine for pseudorabies virus IE180. Submitted revised manuscript to Comparative Immunology, Microbiology and Infectious Diseases 26:175-187.

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