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Faculty

Sylvain De Guise

Background

Degrees

1988 D.M.V. Faculté de Médecine Vétérinaire, Université de Montréal
1990 I.P.S.A.V. (Pathology) Faculté de Médecine Vétérinaire, Université de Montréal
1993 M.Sc. (Pathology) Faculté de Médecine Vétérinaire, Université de Montréal
1996 Ph.D. (Immunotoxicology) Université du Québec à Montréal

Professional experience:

2007- Director, Connecticut Sea Grant College Program
2005-2007 Interim Director, Connecticut Sea Grant College Program
2004- Associate Professor, Department of Pathobiology and Veterinary Science, University of Connecticut
2002- Adjunct Assistant Professor, Department of Environmental and Population Health, Cummings School of Veterinary Medicine at Tufts University
1999- Adjunct Researcher, Mystic Aquarium
1999-2003 Chair, Institutional Animal Care and Use Committee (IACUC), University of Connecticut
1998-2003 Member, Institutional Animal Care and Use Committee (IACUC), University of Connecticut
1998-2004 Assistant Professor, Department of Pathobiology and Veterinary Science, University of Connecticut
1996-1998 Post-Doctoral Fellow, University of California Davis, Davis, CA

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Contact

Department of Pathobiology
University of Connecticut
61 North Eagleville Road, U-3089
Storrs, CT 06269

Phone: (860) 486-0850
Fax: (860) 486-2794
Director, Connecticut Sea Grant College Program
University of Connecticut-Avery Point
Marine Science Building
1080 Shennecossett Road
Groton, CT 06340-6048

Phone: (860) 405-9138
Fax: (860) 405-9109
E-mail: Sylvain.Deguise@uconn.edu

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Courses Taught

PVS 349: Immunobiology. Principles of basic and clinical immunobiology; phylogeny and ontogeny of the immune response, characteristics of the immune response, cellular and humoral immunity; central and peripheral lymphoid tissues; mechanisms of immunologic injury and immunologic diseases; comparative and veterinary immunology; transplantation and tumor immunology.
3 credits, Lecture. Instructor consent required.

PVS 354. Toxicological Pathology. Principles of toxicological pathology are covered, with special attention to chemical carcinogenesis and systemic toxicological pathology. For the different systems, the particularities of structure and function of the system are reviewed, along with the particular mechanisms of toxicity to that system, the specific responses of that system to injury, and the methods to test for toxicity. The discussion of related scientific journal articles supplement the textbook information reviewed in lectures.
2 credits, Lecture. Instructor consent required.

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Research Interests

Dr. De Guise's interests are in immunology, immunotoxicology and pathology of aquatic animals, particularly marine mammals and oysters

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Publications

  • Jenny MJ, Chapman RW, Mancia1 A, Chen YA, McKillen DJ, Trent H, Lang P, Escoubas J-M, Bachere E, Boulo V, Z. Liu J, Gross PS, Cunningham C, Cupit PM, Tanguy A, Guo X, Moraga D, Boutet I, Huvet A, De Guise S, Almeida JS, Warr GW. A cDNA Microarray for Crassostrea virginica and C. gigas. Mar. Biotech., In Press.
  • Levin M, Morsey B, De Guise S. Non-coplanar PCBs induce calcium mobilization in bottlenose dolphins and beluga whales, but not in mice. J Tox Environ Health A, In Press.
  • Levin M, Morsey B, De Guise S. 2007. Modulation of the respiratory burst by organochlorine mixtures in marine mammals, humans and mice. J Tox Environ Health A 70: 73-83.
  • Mori C, Levin M, Morsey B, Nambiar PR, De Guise S. 2006. Immunomodulatory effects of in vitro exposure to organochlorines on T cell proliferation in marine mammals and mice. J Tox Environ Health A 69: 283-302.
  • Mos L, Morsey B, Jeffries SJ, Yunker MB, Raverty S, De Guise S, Ross PS. 2006. Chemical and biological pollution contribute to the immunological profiles of free-ranging harbor seals. Environ Toxicol Chem 25: 3110-3117.
  • McKinney MA, De Guise S, Martineau D, Beland P, Lebeuf M, Letcher RJ. 2006. Organohalogen Contaminants and Metabolites in Beluga Whale (Delphinapterus leucas) Liver from Two Canadian Populations. Environ. Toxicol. Chem. 25: 1246-1257.
  • McKinney MA, De Guise S, Martineau D, Beland P, Arukwe A, Letcher RJ. 2006. Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay. Aquat Toxicol 77: 87-97.
  • Yee A, Dungan C, Hamilton R, Goedken M, De Guise S, Sunila I. 2005. Apoptosis of the protozoan oyster pathogen Perkinsus marinus in vivo and in vitro in the Chesapeake Bay and the Long Island Sound. J. Shellfish Res 24: 1035-1042.
  • Goedken M, Morsey B, Sunila I, De Guise S. 2005. Immunomodulation of Crassostrea gigas and Crassostrea virginica cellular defense mechanisms by Perkinsus marinus. J Shellfish Res 24: 487-496.
  • De Guise S, Morsey B, Maratea J, Goedken M, Sidor I, Atherton J. 2005. Development of assays to evaluate immune functions in the American lobster (Homarus americanus). J Shellfish Res 24:705-711.
  • De Guise S, Maratea J, Chang E, Perkins C. 2005. Resmethrin immunotoxicity and endocrine disrupting effects in the American lobster (Homarus americanus) upon exposure to experimental exposure. J Shellfish Res 24:781-786.
  • Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. 2005. Non-coplanar PCB-mediated modulation of human leukocyte phagocytosis: a new mechanism for immunotoxicity. J Tox Environ Health A 68: 1977-1993.
  • Levin MJ, De Guise S, Ross PS. 2005. Association between lymphocyte proliferation and organochlorine contaminants in recently weaned free-ranging harbor seal (Phoca vitulina) pups from British Columbia, Canada. Environ Toxicol Chem 24: 1247-1252.
  • Ilsley JN, Nakanishi M, Flynn C, Belinsky GS, De Guise S, Adib JN, Dobrowsky RT, Bonventre JV, Rosenberg DW. 2005. Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. Cancer Res. 65: 2636-2643.
  • Goedken M, Morsey B, Sunila I, Dungan C, De Guise S. 2005. The effects of temperature and salinity on apoptosis of Crassostrea virginica hemocytes and Perkinsus marinus. J Shellfish Res 24: 177-183.
  • Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. 2005. PCBs and TCDD, alone and in mixtures, modulate marine mammal but not B6C3F1 mouse leukocyte phagocytosis. J Tox Environ Health A 68: 635-656.
  • Levin MJ, Morsey B, Mori C, De Guise S. 2004. Specific non-coplanar PCB-mediated modulation of bottlenose dolphin and beluga whale phagocytosis upon in vitro exposure. J Toxicol Environ Health A 67: 1517-1535.
  • McKinney MA, Arukwe A, De Guise S, Martineau D, Béland P, Dallaire A, Lair S, Lebeuf M, Letcher RJ. 2004. Characterization and profiling of cytochromes P450 and phase II xenobiotic-metabolizing enzymes in beluga whales (Delphinapterus leucas) from the St. Lawrence River Estuary and the Canadian Arctic. Aquat Toxicol 69: 35-49.
  • De Guise S, Levin MJ. 2004. Cetacean-reconstituted severe combined immuno-deficient (SCID) mice respond to vaccination with canine distemper virus. Vet Immunol Immunopathol 97: 177-186.
  • De Guise S, Maratea J, Perkins C. 2004. Malathion immunotoxicity in the American lobster (Homarus americanus) upon experimental exposure. Aquat Toxicol 66: 419-425.
  • Goedken M, De Guise S. 2004. Flow cytometry as a tool to quantify oyster defense mechanisms. Fish & Shellfish Immunol 16: 539-552.
  • De Guise S, Erickson K, Blanchard M, DiMolfetto L, Lepper H, Stott JL, Ferrick DA. 2004. Characterization of F21.A, a monoclonal antibody that recognize a leucocyte surface antigens for killer whale homologue to ß-2 integrin. Vet Immunol Immunopathol 97: 195-206.
  • Mikaelian I, Labelle P, Kopal M, De Guise S, Martineau D. 2003. Adenomatous hyperplasia of the thyroid gland in beluga whales (Delphinapterus leucas) from the St. Lawrence estuary and Hudson Bay, Quebec, Canada. Vet Pathol 40: 698-703.
  • Bernier J, De Guise S, Martineau D, Beland P, Beaudet M, Fournier M. 2000. Purification of functional T lymphoytes from splenocytes of the beluga whales (Delphinapterus leucas). Dev Comp Immunol, In Press
  • De Guise S, Bernier J, Lapierre P, Dufresne M, Dubreuil P, Fournier M. 2000. Immune function of bovine leucocytes following in vitro exposure to selected heavy metals. Am J Vet Res, 61:339-344
  • Lapierre P, De Guise S, Muir DC, Norstrom R, Beland P, Fournier M. 1999. Immune functions in the Fisher rat fed beluga whale (Delphinapterus leucas) blubber from the contaminated St. Lawrence estuary. Environ Res 80: S104-S112.
  • Mikaelian I, Qualls CW, De Guise S, Martineau D. 1999. Bone fluorine concentrations in beluga whales (Delphinapterus leucas) from the St. Lawrence estuary and from the Canadian Arctic. J Wildl Dis 35: 356-360.
  • Martineau D, Lair S, De Guise S, Lipscomb TP, Béland P. 1999. Cancer in beluga whales from the St Lawrence Estuary, Quebec, Canada: A potential biomarker of environmental contamination. J Cetacean Res Manage (special issue1): 249-265

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