Dr. Xiaohui Zhou Receives NIH R01 Research Grant on Bacterial Pathogenesis

Dr. Xiaohui Zhou, a Pathobiology faculty member, has received a $1.54 million research grant from the National Institute of Health (NIH) in support of his studies on microbial pathogenesis. This 4-year project is entitled “Mechanisms and significance of intestinal cell proliferation in Vibrio parahaemolyticus infection”.

Vibrio parahaemolyticus is a leading cause of seafood-borne diarrheal disease and a multidrug resistant emerging pathogen. However, virulence determinants that are responsible for pathological alterations during infection are not completely defined. The overall objective of this project is to identify proteins that are required for regulating intestinal cell proliferation and determine the role of intestinal cell proliferation in bacterial colonization and virulence. The successful implementation of this project could result in new and innovative approaches for the prevention and treatment of infection caused by V. parahaemolyticus, and potentially other important enteric pathogens.

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